It’s a nice thought, but I’m not holding my breath; at the end of this thread Access Virus emulator on Zynthian? - #5 by JayBee it was concluded that the RPi4 is probably too slow even if the emulator can be improved and the Pi overclocked.
Indeed, as a (very) loose MIPS comparison, a while ago, I tried running the test application that the Osiris team brought out on a ten year old laptop (i5-2450M), which is about as powerful in terms of CPU power as the RPi4, and as I recall it didn’t even managed to run the Virus B successfully.