Here we go. It’s more important for the Jack period / buffer settings to set up whole integer latencies for usb devices, e.g. 10ms rather than 10.33333 ms, having 2 or 3 periods is pretty irrelevent.
https://wiki.linuxaudio.org/wiki/list_of_jack_frame_period_settings_ideal_for_usb_interface
improvements in kernel 5.16 Linux 5.16 Aims For Better USB Low-Latency Audio Playback - Phoronix