Nice, guys!! Let’s do it …
The MCP23017 and ADS1115 are currently well supported by the wiringPi library, and MCP23017 support has been extended a little bit for zynthian (see the zyncoder library). I don’t think we need extra “i2c-low-level” coding for this 2 chips.
The MCP4728 is not supported by the wiringPi library, but there is code for arduino, so we can use it for adding wiringPi support:
https://github.com/hideakitai/MCP4728
It’s always a funny task to add support for new hardware in a platform like RBPi. A lot of people will take profit from this!! 
In the meanwhile, we should define how CV/Gate should be integrated with zynthian engines. The obvious starting point is mapping to MIDI events, of course … but you know, devil is on details 
Regards,