I have a Tascam US 4x4 - the four channel version, and it works well including MIDI.
To enter the configuration you have to use the “Generic USB device” Soundcard, click on “Advanced view” and put the following into the JackD Options field (yours will probably listed as US2x2):
-P 70 -t 2000 -s -d alsa -d hw:US4x4 -r 48000 -p 256 -n 3 -X raw
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