Speaking of cascaded latency, did you see “The World’s Largest Pedal Board”
The speed of sound is 2.92 meters/ms, a monitor on the other end of a stadium gig stage might add around 10 ms delay, no point, just for reference.
I assume USB can provide a programmable wiring configurations of virtual cables.
One guide recommends a limit of 30 meters for USB 2.0, and 18 meters USB 3.0/3.1 (just pondering what hubs and repeaters? might be necessary in a large studio)